Biomarker: Insulin
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Insulin
| Description | After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] Source |
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| Gene Symbol | INS Gene |
| Protein Name | insulin Uniprot |
| Synonyms | Insulin; IDDM and 9 more synonyms used to describe this biomarker that Amplion uses in its algorithms. |
Associated Biomarker Indications
